AN301731L
Recombinant Calmodulin 1/2/3 Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301731L
- Zusätzliche Namen:
- CALM1,CALM2,CALM3
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human Calmodulin 1/2/3 fragment
- Klon:
- A439
- Uniprot:
- P0DP23, P0DP24, P0DP25
- Synonyme:
- CALM;CALML2;calmodulin 1 (phosphorylase kinase, delta);calmodulin 2 (phosphorylase kinase, delta);calmodulin-1;Calmodulin-2;Calmodulin-3;caM;CAM1;CAM2;CAM3;CAMB;CAMC;CAMI;CAMII;CAMIII;CPVT4;CPVT6;DD132;epididymis secretory protein Li 72;HEL-S-72;LP7057 protein;LQT14;LQT15;LQT16;PHKD;PHKD2;PHKD3;phosphorylase kinase delta;phosphorylase kinase subunit delta;phosphorylase kinase, delta subunit;prepro-calmodulin 1;prepro-calmodulin 2;prepro-calmodulin 3
- Weitere Details:
- Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calmodulin (CaM) is a ubiquitously expressed Ca2+ binding protein best known for its ability to activate CaM-dependent kinases in a variety of cells. It was initially identified in its role as an activator of cAMP PDE. In fact, calmodulin was first known as the calcium-dependent regulator protein of PDE. Calmodulin is involved, directly and indirectly, in modulation of several ion channels, including Na+, K+, L-type Ca2+, and RYR2 channels. The main binding partner of calmodulin in cardiac cells is RyR2, which regulates Ca2+ release from the sarcoplasmic reticulum. Acting as an intracellular Ca2+ sensor, Ca2+-saturated calmodulin binds RYR2 to inhibit Ca2+ release by stabilizing the RyR2 channel closed state.
- Versandbedingungen:
- Blue Ice