Recombinant ClC-2 Monoclonal Antibody

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£252.90

War £281.00

SKU:: AN301722L
Zusätzliche Namen:: CIC,CLCN,EJM,EGI,CLC,ECA,CLCN2,CIC-2,CLC2,ECA2,ECA3,EGI11,EGI3,EGMA,EJM6,EJM8,LKPAT,clC-2
Anwendung:: IHC, WB
Konzentration:: 1 mg/ml
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human ClC-2 fragment
Klon:: A430
Uniprot:: P51788
Synonyme:: chloride channel 2;chloride channel protein 2;chloride channel, voltage-sensitive 2;CIC-2;clC-2;CLC2;ECA2;ECA3;EGI11;EGI3;EGMA;EJM6;EJM8;HALD2;LKPAT
Weitere Details:: ClC-2 (chloride channel protein 2) is a transmembrane protein and functions as a voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. ClC-2 is highly expressed in adrenal gland and involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis. Defects in this gene may be a cause of certain epilepsies.