AN301622L
Recombinant PDK1 Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301622L
- Zusätzliche Namen:
- PDK,PDHK,PDK1,PDHK1
- Anwendung:
- IHC, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human PDK1 fragment
- Klon:
- A325
- Uniprot:
- Q15118
- Synonyme:
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial;mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1;PDH kinase 1;pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial;Pyruvate dehydrogenase kinase isoform 1;pyruvate dehydrogenase kinase, isoenzyme 1
- Weitere Details:
- Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
- Versandbedingungen:
- Blue Ice