AN301572L
Recombinant PCAF Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN301572L
- Zusätzliche Namen:
- KAT2B,CAF,P/CAF,PCAF
- Anwendung:
- WB, IP
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human PCAF fragment
- Klon:
- A271
- Uniprot:
- Q92831
- Synonyme:
- CAF;CREBBP-associated factor;histone acetylase PCAF;histone acetyltransferase KAT2B;histone acetyltransferase PCAF;K(lysine) acetyltransferase 2B;Lysine acetyltransferase 2B;P/CAF;p300/CBP-associated factor;PCAF;spermidine acetyltransferase KAT2B
- Weitere Details:
- Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Also acetylates spermidine. (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
- Versandbedingungen:
- Blue Ice