AN301556L
Recombinant Homer1 Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301556L
- Zusätzliche Namen:
- Vesl,HOMER,Vesl1,Homer1
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human Homer1 fragment
- Klon:
- A255
- Uniprot:
- Q9Z2Y3
- Synonyme:
- homer homolog 1;homer protein homolog 1;homer-1;homer, neuronal immediate early gene, 1;immediate early gene protein Homer1A;PSD-Z;PSD-Zip45;SYN47;VASP/Ena-related gene up-regulated during seizure and LTP 1;Ves;Ves-1;vesl-1
- Weitere Details:
- Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
- Versandbedingungen:
- Blue Ice