AN301541L
Recombinant GRK2 Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301541L
- Zusätzliche Namen:
- GRK,Adrenergic beta receptor kinase,Beta adrenergic receptor kinase,Beta-adrenergic receptor kinase,G protein coupled receptor kinase,G-protein coupled receptor kinase,ARBK,ADRBK,GRK2,ADRBK1,BARK1,BETA-ARK1,Adrenergic beta receptor kinase 1,ARBK1,Beta adrenergic receptor kinase 1,Beta ARK 1,Beta ARK1,Beta-adrenergic receptor kinase 1,Beta-ARK-1,FLJ16718,G protein coupled receptor kinase 2,G-protein coupled receptor kinase 2,BARK
- Anwendung:
- WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human GRK2 fragment
- Klon:
- A240
- Uniprot:
- P25098
- Synonyme:
- ADRBK1;adrenergic beta receptor kinase 1;BARK1;beta-adrenergic receptor kinase 1;beta-ARK-1;BETA-ARK1;G-protein coupled receptor kinase 2
- Weitere Details:
- Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light.
- Versandbedingungen:
- Blue Ice