Recombinant CCR6 Monoclonal Antibody

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£252.90

War £281.00

SKU:: AN301459L
Zusätzliche Namen:: DCR,DRY,GPR,CKRL,STRL,CKR-L,CMKBR,GPRCY,CC-CKR,C-C CKR,CCR,CCR6,BN-1,C-C CKR-6,CC-CKR-6,CCR-6,CD196,CKR-L3,CKRL3,CMKBR6,DCR2,DRY6,GPR29,GPRCY4,STRL22,BN 1,BN1,C C chemokine receptor type 6,C C CKR 6,CC chemokine receptor type 6,C-C chemokine receptor type 6,CC CKR 6,CC R6,CCCKR6,CCR 6,CD 196,CD196 antigen,Chemokine (C C motif) receptor 6,Chemokine (C C) receptor 6,Chemokine (CC motif) receptor 6,Chemokine (CC) receptor 6,Chemokine receptor 6,Chemokine receptor like 3,Chemokine receptor-like
Anwendung:: IHC, WB
Konzentration:: 1 mg/ml
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human CCR6 fragment
Klon:: A154
Uniprot:: P51684
Synonyme:: BN-1;C-C chemokine receptor type 6;C-C CKR-6;CC-CKR-6;CCR-6;CD196;chemokine (C-C motif) receptor 6;chemokine (C-C) receptor 6;chemokine receptor-like 3;CKR-L3;CKRL3;CMKBR6;DCR2;DRY6;G protein-coupled receptor 29;G-protein coupled receptor 29;GPR-CY4;GPR29;GPRCY4;LARC receptor;seven-transmembrane receptor, lymphocyte, 22;STRL22
Weitere Details:: Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma.

Versandbedingungen:: Blue Ice