AN301458L
Recombinant CBX2 Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN301458L
- Zusätzliche Namen:
- CBX,CDCA,SRXY,CBX2,CDCA6,M33,SRXY5
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Synthetic peptide derived from the human CBX2 protein
- Klon:
- A153
- Uniprot:
- Q14781
- Synonyme:
- CDCA6;cell division cycle associated 6;chromobox homolog 2 (Pc class homolog, Drosophila);chromobox protein homolog 2;M33;modifier 3;Pc class homolog;SRXY5
- Weitere Details:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.
- Versandbedingungen:
- Blue Ice