Recombinant Aurora B Monoclonal Antibody

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£252.90

War £281.00

SKU:: AN301441L
Zusätzliche Namen:: IPL,ARK,AIK,AIRK,PPP1R,STK,AIM,AIK2,AIM-1,AIM1,ARK2,AurB,IPL1,PPP1R48,STK12,STK5,aurkb-sv1,aurkb-sv2,AURKB,Aurora B,AIRK2,STK1
Anwendung:: IHC, WB, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human Aurora B fragment
Klon:: A136
Uniprot:: Q96GD4
Synonyme:: AIK2;AIM-1;AIM1;ARK-2;ARK2;AurB;aurkb-sv1;aurkb-sv2;Aurora 1;aurora kinase B;aurora kinase B-Sv1;aurora kinase B-Sv2;aurora- and Ipl1-like midbody-associated protein 1;aurora-1;aurora-B;aurora-related kinase 2;aurora/IPL1-related kinase 2;IPL1;PPP1R48;protein phosphatase 1, regulatory subunit 48;serine/threonine kinase 12;serine/threonine-protein kinase 12;serine/threonine-protein kinase 5;serine/threonine-protein kinase aurora-B;STK-1;STK12;STK5
Weitere Details:: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis.

Versandbedingungen:: Blue Ice