Recombinant 53BP1 Monoclonal Antibody

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£311.40

War £346.00

SKU:: AN301369L
Zusätzliche Namen:: 53BP,TDRD,tumor protein p53 binding protein,p53BP,TP53BP,TP53BP1,53BP1,TDRD30,TP53,p202,p53BP1,tumor protein p53 binding protein 1,53BP1,p202,p53BP1,TDRD30,TP53,tumor protein p53 binding protein 1
Anwendung:: IHC, WB
Konzentration:: 0.2 mg/ml
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant Human 53BP1 protein
Klon:: B1136
Uniprot:: Q12888
Synonyme:: 53BP1;p202;p53-binding protein 1;p53BP1;TDRD30;TP53-binding protein 1;tumor protein 53-binding protein, 1;tumor suppressor p53-binding protein 1
Weitere Details:: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.