AN301106L
Recombinant Collagen IV Monoclonal Antibody
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£221.40
War £246.00
- SKU:
- AN301106L
- Zusätzliche Namen:
- COL4A,POREN,alpha 1 chain,Arresten,COL4A1 NC1 domain,Collagen alpha-1(IV) chain,Collagen IV alpha-1 polypeptide,Collagen of basement membrane,HANAC,ICH,POREN1,COL4A1,Type-IV Collagen
- Anwendung:
- IHC, WB
- Konzentration:
- 0.2 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human Collagen IV protein
- Klon:
- B861
- Uniprot:
- P02462
- Synonyme:
- arresten;BSVD;BSVD1;COL4A1 NC1 domain;COL4A1s;collagen alpha-1(IV) chain;collagen IV, alpha-1 polypeptide;collagen of basement membrane, alpha-1 chain;PADMAL;RATOR
- Weitere Details:
- This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
- Versandbedingungen:
- Blue Ice