AN300594P
Recombinant CD3D & CD3E Monoclonal Antibody
Größe
£170.10
War £189.00
- SKU:
- AN300594P
- Zusätzliche Namen:
- IMD,CD3E,IMD18,T3E,TCRE,CD3e molecule,CD3 epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain,T3,CD_antigen: CD3e,epsilon
- Anwendung:
- Flow Cytometry, IHC-P
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human CD3D & CD3E Heterodimer protein
- Klon:
- B529
- Uniprot:
- P04234, P07766
- Synonyme:
- CD3 antigen, delta subunit;CD3 delta;CD3-DELTA;CD3-epsilon;CD3d antigen, delta polypeptide (TiT3 complex);CD3d molecule, delta (CD3-TCR complex);CD3e antigen, epsilon polypeptide (TiT3 complex);CD3e molecule, epsilon (CD3-TCR complex);IMD18;IMD19;OKT3, delta chain;T-cell antigen receptor complex, epsilon subunit of T3;T-cell receptor T3 delta chain;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell surface glycoprotein CD3 delta chain;T-cell surface glycoprotein CD3 epsilon chain;T3D;T3E;TCRE
- Weitere Details:
- The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
- Versandbedingungen:
- Blue Ice