AN300575P
Recombinant PDGF alpha receptor/PDGFRA Monoclonal Antibody
Größe
£311.40
War £346.00
- SKU:
- AN300575P
- Zusätzliche Namen:
- Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a,PDGFR-alpha,PDGF-R-alpha,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor alpha,Pdgfra,PDGF-R&,alpha
- Anwendung:
- IHC-P
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse PDGF alpha receptor/PDGFRA Protein
- Klon:
- B510
- Uniprot:
- P26618
- Synonyme:
- AI115593;Alpha platelet-derived growth factor receptor;Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha);alpha-type platelet-derived growth factor receptor;CD140;CD140 antigen-like family member A;CD140a;PDGF alpha chain;PDGF-R-alpha;Pdgfr;Pdgfr-2;PDGFR-alpha;Platelet-derived growth factor alpha receptor;platelet-derived growth factor receptor alpha
- Weitere Details:
- PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.
- Versandbedingungen:
- Blue Ice