AN300574P
Recombinant CD22 Monoclonal Antibody
Größe
£361.80
War £402.00
- SKU:
- AN300574P
- Zusätzliche Namen:
- Lyb,SIGLEC2FLJ,B-cell receptor CD,T-cell surface antigen Leu,sialic acid binding Ig-like lectin,Sialic acid-binding Ig-like lectin,B-cell receptor CD22,BL-CAM,B-lymphocyte cell adhesion molecule,CD22 antigenMGC130020,CD22 molecule,sialic acid binding Ig-like lectin 2,Sialic acid-binding Ig-like lectin 2,Siglec-2,SIGLEC2FLJ22814,T-cell surface antigen Leu-14,Lyb-8,Siglec2,Cd22,Lyb8,Siglec-2
- Anwendung:
- WB, IP
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse CD22 Protein
- Klon:
- B509
- Uniprot:
- P35329
- Synonyme:
- A530093D23;B-cell receptor CD22;B-lymphocyte cell adhesion molecule;BL-CAM;Lyb;Lyb-;Lyb-8;Lyb8;sialic acid-binding Ig-like lectin 2;siglec-2;T-cell surface antigen Leu-14
- Weitere Details:
- CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.
- Versandbedingungen:
- Blue Ice