Recombinant IL36B/IL1F8 Monoclonal Antibody

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£361.80

War £402.00

SKU:: AN300570P
Zusätzliche Namen:: Il1f,Interleukin-1 family member,IL-1F,IL-1F8,Interleukin-1 family member 8,Interleukin-36 beta,Fil1e,Il1f8,Il36b
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Mouse
Buffer:: PBS
Immunogen:: Recombinant Mouse IL36B/IL1F8 Protein
Klon:: B505
Uniprot:: Q9D6Z6
Synonyme:: 2310043N20Rik;If36b;IL-1F8;Il1f8;interleukin 1 family, member 8;Interleukin-1 family member 8;interleukin-36 beta
Weitere Details:: Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includes four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-K KappaB.