Recombinant TROP-2/TACSTD2 Monoclonal Antibody

Größe

£170.10

War £189.00

SKU:: AN300565P
Zusätzliche Namen:: EGP,Cell surface glycoprotein Trop,Tumor-associated calcium signal transducer,GA733,TACSTD,C80403,Cell surface glycoprotein Trop-2,EGP-1,GA733-1,Ly97,TROP-2,Tumor-associated calcium signal transducer 2,Trop2,Tacstd2
Anwendung:: IHC-P
Konzentration:: 1 mg/ml
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Mouse
Buffer:: PBS
Immunogen:: Recombinant Mouse TROP-2/TACSTD2 protein
Klon:: B495
Uniprot:: Q8BGV3
Synonyme:: C80403;cell surface glycoprotein Trop-2;EGP-;EGP-1;GA733-;GA733-1;Ly9;Ly97;lymphocyte antigen 97;TR;TROP2;tumor-associated calcium signal transducer 2;tunor-associated calcium signal transducer 2
Weitere Details:: TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.

Versandbedingungen:: Blue Ice