AN300553P
Recombinant Syndecan-4/SDC4 Monoclonal Antibody
Größe
£170.10
War £189.00
- SKU:
- AN300553P
- Zusätzliche Namen:
- SDC,syndecan,AA959608,Amphiglycan,AW108331,Ryudocan,Ryudocan core protein,SYND4,syndecan-4,Sdc4
- Anwendung:
- Flow Cytometry, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse Syndecan-4/SDC4 protein
- Klon:
- B483
- Uniprot:
- O35988
- Synonyme:
- AA959608;AW108331;ryud;ryudocan;ryudocan core protein;S;S4;Syn;Synd4;syndec;syndecan-4
- Weitere Details:
- SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with several signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.
- Versandbedingungen:
- Blue Ice