AN300547P
Recombinant CD23/FCER2 Monoclonal Antibody
Größe
£361.80
War £402.00
- SKU:
- AN300547P
- Zusätzliche Namen:
- Fce,FCER,CD23,Fce2,Fc-epsilon-RII,Ly-42,Lymphocyte IgE receptor,Fcer2a,Fcer2,Fc&,epsilon-RII-I,Ly-42,BLAST-2,CD23A,CLEC4J,Fc epsilon RII,IGEBF
- Anwendung:
- Flow Cytometry, IF, ICC
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse CD23/FCER2 Protein
- Klon:
- B477
- Uniprot:
- P20693
- Synonyme:
- CD23;FC epsilon RII;fc-epsilon-RII;Fce2;Fcer2;low affinity immunoglobulin epsilon Fc receptor;low-affinity IgE receptor;Ly-4;Ly-42;lymphocyte IgE receptor
- Weitere Details:
- CD23, also known as FcE EpsilonRII, is a trimeric type II transmembrane glycoprotein member of the calcium-dependent (C-type) lectin family. CD23 is expressed in B and T lymphocytes, monocytes, polymorphonuclear leukocytes, follicular dendritic cells, intestinal epithelial cells, and bone marrow stromal cells. CD23 was first identified as a low-affinity receptor for IgE and the engagement of membrane bound CD23 leads to suppressed IgE production by B lymphocytes. CD23 can be cleaved to form a soluble protein which can drive cytokine release in monocytic cells, nitric oxide (NO) production, and the synthesis of cyclic adenosine 3'5'-monophosphate (cAMP). Soluble CD23 signals through integrins, activating MAPK and NF-K KappaB pathways. CD23 is a useful marker in the prognosis of neoplastic disease, is elevated in a variety of autoimmune and inflammatory conditions, and is being investigated as a therapeutic target for IgE-mediated allergy, arthritis, and B cell chronic lymphocytic leukemia (CLL).
- Versandbedingungen:
- Blue Ice