AN300500P
Recombinant Ly108/SLAMF6 Monoclonal Antibody
Größe
£361.80
War £402.00
- SKU:
- AN300500P
- Zusätzliche Namen:
- SLAMF,Ly108,Slamf6,NTB-A,KAL1,Ly108
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse Ly108/SLAMF6 Protein
- Klon:
- B430
- Uniprot:
- Q9ET39
- Synonyme:
- KA;KAL;KAL1;KAL1b;Ly10;Ly108;lymphocyte antigen 108;NTB;NTB-A;NTBA;SF200;SF2000;SLAM family member 6
- Weitere Details:
- SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6/Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6/Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6/Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6/Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6/Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
- Versandbedingungen:
- Blue Ice