AN300413P
Recombinant SNCA/alpha-Synuclein Monoclonal Antibody
Größe
£170.10
War £189.00
- SKU:
- AN300413P
- Zusätzliche Namen:
- Fetal liver kinase,Protein-tyrosine kinase receptor flk,Vascular endothelial growth factor receptor,PD1,NACP,PARK1,PARK4,SNCA,SNC-A,aSYN,CD309,Fetal liver kinase 1,FLK1,FLK-1,KDR,Kinase insert domain receptor,Protein-tyrosine kinase receptor flk-1,Vascular endothelial growth factor receptor 2,VEGFR,VEGFR2,VEGFR-2,Alpha-synuclein,Non-A beta component of AD amyloid,Non-A4 component of amyloid precursor,PARK1,alpha (non A4 component of amyloid precursor),Alpha synuclein,alphaSYN,isoform
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human SNCA/alpha-Synuclein protein
- Klon:
- 5D12
- Uniprot:
- P37840
- Synonyme:
- alpha-synuclein;I+/--synuclein;NACP;non A-beta component of AD amyloid;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;PARK1;PARK4;PD1;synuclein alpha-140;synuclein, alpha (non A4 component of amyloid precursor);truncated alpha synuclein
- Weitere Details:
- Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
- Versandbedingungen:
- Blue Ice