AN300264P
Recombinant TSPAN1 Monoclonal Antibody
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£361.80
War £402.00
- SKU:
- AN300264P
- Zusätzliche Namen:
- NET,TSPAN,TM4C,TM4SF,NET1,TSPAN1
- Anwendung:
- Flow Cytometry, IHC-P
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human TSPAN1 Protein
- Klon:
- B182
- Uniprot:
- O60635
- Synonyme:
- NET1;tetraspan 1;Tetraspan NET-1;Tetraspanin TM4-C;tetraspanin-1;TM4C;TM4SF
- Weitere Details:
- TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-8 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone, in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.
- Versandbedingungen:
- Blue Ice