Claudin18.2 Monoclonal Antibody

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£311.40

War £346.00

SKU:: AN200149P
Zusätzliche Namen:: UNQ,PRO,CLDN,SFTA,Claudin,Claudin-,CLDN18,SFTA5,SFTPJ,Claudin-18,Claudin-18.2,UNQ778,PRO1572,SPJ
Anwendung:: WB, IHC-P
Konzentration:: 1 mg/ml
Aufreinigung:: Protein A Purified
Lagerbedingungen:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS
Immunogen:: Human Claudin18.2 mRNA
Klon:: A1001
Uniprot:: P56856
Synonyme:: claudin-18;SFTA5;SFTPJ;surfactant associated 5;surfactant associated protein J;surfactant, pulmonary associated protein J
Weitere Details:: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-2) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.