AN200053P
SETD7/SET7/9 Monoclonal Antibody
Größe
£311.40
War £346.00
- SKU:
- AN200053P
- Zusätzliche Namen:
- KMT,SETD,KIAA,SET,SETD7,KMT7,SET7,SET7/9,SET9,KIAA1717
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human SETD7 / SET7 / 9 protein
- Klon:
- A901
- Uniprot:
- Q8WTS6
- Synonyme:
- H3-K4-HMTase SETD7;histone H3-K4 methyltransferase SETD7;histone H3-lysine 4-specific methyltransferase;histone-lysine N-methyltransferase SETD7;KMT7;lysine N-methyltransferase 7;SET domain containing 7, lysine methyltransferase;SET domain containing lysine methyltransferase 7;SET domain-containing protein 7;SET7;SET7/9;SET9
- Weitere Details:
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP50-mediated transcriptional activation.
- Versandbedingungen:
- Blue Ice