AN00962E
APC Anti-Mouse CD123 Antibody[5B11]
Größe
£64.80
War £72.00
- SKU:
- AN00962E
- Zusätzliche Namen:
- IL-3 Receptor A Alpha chain,IL-3RA Alpha
- Anwendung:
- Flow Cytometry
- Konzentration:
- 5 ul/test
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Host:
- Rat
- Reaktivitäten:
- Mouse
- Buffer:
- PBS
- Immunogen:
- CD123
- Klon:
- 5B11
- Uniprot:
- Q8CII2
- Synonyme:
- AA959893;CD123;CDw123;cell division cycle 123 homolog;cell division cycle protein 123 homolog;G431001I09Rik;Il-3 alpha subunit;IL-3 receptor alpha chain;IL-3 receptor subunit alpha;IL-3R subunit alpha;IL-3R-alpha;IL-3RA;interleukin-3 receptor class II alpha chain;interleukin-3 receptor subunit alpha;SUT-;SUT-1
- Weitere Details:
- CD123 is a 70 kD A Alpha chain subunit of the IL-3 receptor (IL-3R A Alpha). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common B Beta chain (CDw131) or the IL-3R B Beta chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the A Alpha subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R B Beta subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.
- Versandbedingungen:
- Blue Ice