GRP78 Polyclonal Antibody

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£120.60

War £134.00

SKU:: AN006780L
Zusätzliche Namen:: 78 kDa glucose-regulated protein, BIP, Binding-immunoglobulin protein, Endoplasmic reticulum chaperone BiP, GRP, GRP-78, GRP78, HEL-S-89n, HSP70 family protein, HSP70 family protein 5, HSPA, HSPA5, Heat shock protein family A member, Immunoglobulin heavy chai, MIF, MIF2
Anwendung:: WB
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
Immunogen:: Recombinant Human GRP78 protein expressed by E.coli
Uniprot:: P11021
Synonyme:: 78 kDa glucose-regulated protein;binding-immunoglobulin protein;BIP;endoplasmic reticulum chaperone BiP;endoplasmic reticulum lumenal Ca(2+)-binding protein grp78;epididymis secretory sperm binding protein Li 89n;glucose-regulated protein, 78kDa;GRP78;heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa);heat shock protein 70 family protein 5;heat shock protein family A member 5;HEL-S-89n;HSP70 family protein 5;immunoglobulin heavy chain-binding protein
Weitere Details:: GRP78 (Glucose-regulated protein 78 kDa, also BiP and HSPA5) is a 72 kDa member of the heat shock protein 70 family of proteins. Intracellularly, GRP78 is an endoplasmic reticulum chaperone that participates in protein folding, extracellularly, it induces IL-10 production from T cells and interacts with Cripto to block TGF-beta signaling. Human GRP78 precursor is 654 amino acids (aa) in length. It contains an 18 aa signal sequence and a 636 aa mature region that shows a hydantoinase A region (aa 145-245) and a C-terminal KDEL motif that is present on intracellular GRP78, but absent on secreted GRP78. There is alternative splicing in the signal sequence (aa 1-10), and multiple single aa substitituion. Over aa 1-654, human GRP78 is more than 97% aa identical to mouse and rat GRP78.

Versandbedingungen:: Blue Ice