FITC Anti-Human CD156c(ADAM10) Antibody[11G2]

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£130.50

War £145.00

SKU:: AN00355C
Zusätzliche Namen:: MADM,KUZ,alpha-secretase
Anwendung:: Flow Cytometry
Lagerbedingungen:: 2-8[o]C Do not freeze. Protect from light.
Hersteller:: Elabscience
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS
Immunogen:: CD156c
Klon:: 11G2
Uniprot:: O14672
Synonyme:: a disintegrin and metalloprotease domain 10;AD10;AD18;antigen recognized by monoclonal antibody 5.1H11;CD156c;CD56;CDw156;disintegrin and metalloproteinase domain-containing protein 10;HsT18717;kuz;kuzbanian protein homolog;MADM;mammalian disintegrin-metalloprotease;MSK39;NCAM;neural cell adhesion molecule 1;neural cell adhesion molecule, NCAM;RAK
Weitere Details:: CD156c, also known as a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), is a 748 amino acid type I membrane glycoprotein ubiquitously expressed on most cell types. It consists of multiple functional domains, including a N-terminal prodomain, catalytic domain, cysteine-rich domain, transmembranous domain, and cytoplasmic domain. It is secreted as a precursor protein and becomes as the activate/mature form through removing the ADAM10 prodomain by proprotein convertase 7 and furin. ADAM10 functions as metalloproteinase to cleave several molecules including Notch, pro-TNF-A Alpha, amyloid precursor protein, myelin basic protein, and type IV collagen. It mediates the release of several cell adhesion molecules such as vascular endothelial cadherin or L-selectin to regulate endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases.

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