APC Anti-Human CD329 Antibody[K8]

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£124.20

War £138.00

SKU:: AN00319E
Zusätzliche Namen:: Siglec-9,Sialic acid-binding Ig-like lectin-9
Anwendung:: Flow Cytometry
Lagerbedingungen:: 2-8[o]C Do not freeze. Protect from light.
Hersteller:: Elabscience
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS
Immunogen:: CD329
Klon:: K8
Uniprot:: Q9Y336
Synonyme:: CD329;CDw329;FOAP-9;OBBP-LIKE;protein FOAP-9;sialic acid-binding Ig-like lectin 9;siglec-9
Weitere Details:: Siglecs are cell surface receptors belonging to the immunoglobulin superfamily that recognize sugar antigens. The extracellular domain of siglec-9 contains an IgV region, which binds sialic acid, followed by two IgC regions. Siglec 9 and siglec 6-8,10-12 are CD33 (siglec 3) like siglecs, which have two ITIMs in the cytoplasmic tails, suggesting their functional involvement in signal transduction. It is highly expressed on neutrophils and monocytes, and at lower levels on the subpopulations of T and B lymphocytes and NK cells. Siglec-9 plays a role in negative regulation of T cell activation, and it also affects neutrophil apoptosis.