AN00317E
APC Anti-Human CD172a/b Antibody[SE5A5]
Größe
£117.90
War £131.00
- SKU:
- AN00317E
- Zusätzliche Namen:
- SIRPa,SIRPb,SIRPalpha/beta,BIT,SHPS1,MFR,P84,PTPNS1,CD172 antigen-like family member A,CD172 antigen-like family member B
- Anwendung:
- Flow Cytometry
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS
- Immunogen:
- CD172a/b
- Klon:
- SE5A5
- Uniprot:
- O00241
- Synonyme:
- BIT;brain-immunoglobulin-like molecule with tyrosine-based activation motifs;CD172 antigen-like family member A;CD172 antigen-like family member B;CD172A;CD172b;inhibitory receptor SHPS-1;macrophage fusion receptor;MFR;MYD-1;myd-1 antigen;P84;PTPNS1;SHPS1;signal-regulatory protein beta-1;SIRP;SIRP-BETA-1;tyrosine phosphatase SHP substrate 1;tyrosine-protein phosphatase non-receptor type substrate 1
- Weitere Details:
- CD172a, also known as signal-regulatory protein A Alpha (SIRPA Alpha), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPA Alpha was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.
- Versandbedingungen:
- Blue Ice