Y11621H
Recombinant Human FGF-19
Größe
£396.00
- SKU:
- Y11621H
- Zusätzliche Namen:
- FGF19, FGF-19, Fibroblast growth factor 19
- Anwendung:
- Functional Assay
- Molekulargewicht:
- 21.2 kDa
- Reinheit:
- ≥95% by SDS-PAGE
- Lagerbedingungen:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Hersteller:
- East-Mab Biomedical
- Host:
- E. coli
- ABP:
- No Import Docs
- Formulierung:
- Lyophilized from a 0.22 um filtered solution containing 20mM Sodium acetate, 5% Trehalose and 0.01% Tween 80, pH2.5
- Format:
- Lyophilized powder
- Weitere Details:
- FGF-19 (Fibroblast Growth Factor 19) is an endocrine member of the FGF family, primarily produced in the intestine and released into circulation. It signals through FGFR4 in combination with the co-receptor β-Klotho, activating downstream pathways such as MAPK and PI3K-AKT to regulate metabolic processes. Functionally, FGF-19 plays a key role in bile acid homeostasis, glucose and lipid metabolism, and liver regeneration. In *in vitro* cell and organoid culture systems, FGF-19 is commonly used to support hepatocyte expansion, maintain metabolic function, and improve the physiological relevance of liver and intestinal organoid models. Dysregulation of FGF-19 signaling is associated with metabolic disorders and liver disease.
- Versandbedingungen:
- Blue Ice