Y06601H
Recombinant Human IL-17A
Größe
£355.00
- SKU:
- Y06601H
- Zusätzliche Namen:
- IL-17A, Interleukin-17A, CTLA-8, IL-17
- Anwendung:
- Functional Assay
- Molekulargewicht:
- 15.5 kDa
- Reinheit:
- ≥95% by SDS-PAGE
- Lagerbedingungen:
- 36 months at-20°C to-80°C in lyophilized state; 6 months at-20°C to-80°C under sterile conditions after reconstitution; 7-10 days at 2°C to 8°C under sterile conditions after reconstitution; Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- Hersteller:
- East-Mab Biomedical
- Host:
- Hamster
- ABP:
- No Import Docs
- Formulierung:
- Lyophilized from a 0.22 um filtered solution containing PBS, 5% Mannitol, 0.01% Tween 80, pH7.4
- Format:
- Lyophilized powder
- Weitere Details:
- IL-17A (Interleukin-17A) is a pro-inflammatory cytokine mainly produced by Th17 cells, as well as γδ T cells and innate lymphoid cells. It signals through the IL-17RA/IL-17RC receptor complex, activating NF-κB and MAPK pathways to induce inflammatory responses. Functionally, IL-17A promotes chemokine and cytokine production, drives neutrophil recruitment, and plays a key role in mucosal defense against extracellular bacteria and fungi. In in vitro cell and organoid models, IL-17A is commonly used to mimic inflammatory microenvironments and often acts synergistically with TNF-α or IL-22. Dysregulated IL-17A signaling is implicated in autoimmune and chronic inflammatory diseases such as psoriasis and inflammatory bowel disease.
- Versandbedingungen:
- Blue Ice