BNUM3111
ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target)(ICOSL/3111), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM3111
- Zusätzliche Namen:
- B7 homolog 2 (B7H2); B7 like protein Gl50; B7 related protein 1 (B7RP1); CD275; CD275 antigen; GL50; ICOS LG; ICOS ligand (ICOSL); Inducible T cell co stimulator ligand; LICOS; Transmembrane protein B7 H2 ICOS ligand
- Anwendung:
- Flow Cytometry, IHC-P, IF
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 36 kda
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149) (exact sequence is proprietary)
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- ICOSL/3111
- Uniprot:
- O75144
- Synonyme:
- B7 homolog 2;B7 homologue 2;B7-H2;B7-like protein Gl50;B7-related protein 1;B7h;B7H2;B7RP-1;B7RP1;CD275;F1A-alpha;fem-1-like death receptor-binding protein alpha;fem-1-like in apoptotic pathway protein alpha;FEM1-beta;feminization 1 homolog b;GL50;ICOS ligand;ICOS-L;ICOSL;LICOS;mKIAA0396;mt-Fem;protein fem-1 homolog B;transmembrane protein B7-H2 ICOS ligand
- Weitere Details:
- This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2. 4, 3. 0, and 7. 0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1. 1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient