BNUM2840
Desmoglein-3 (Squamous Cell Marker)(DSG3/2840), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM2840
- Zusätzliche Namen:
- 130kDa pemphigus vulgaris antigen (PVA); Balding (Bal); Cadherin family member 6 (CDHF6); Desmoglein-3 (DSG3)
- Anwendung:
- IHC-P
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 130 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- DSG3/2840
- Uniprot:
- P32926
- Synonyme:
- 130 kDa pemphigus vulgaris antigen;ABOLM;cadherin family member 6;CDHF6;desmoglein-3;PVA
- Weitere Details:
- Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient