MSH2 (DNA Mismatch Repair Marker)(MSH2/2622), 1mg/mL

Eine Lieferung in diese Region ist nicht möglich.

SKU:: BNUM2622
Zusätzliche Namen:: BAT26; COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC1; LCFS2; MSH2; MutS homolog 2; MutS homolog 2 colon cancer nonpolyposis type 1; MutS protein homolog 2
Anwendung:: Flow Cytometry, WB, IHC-P, IF
Konzentration:: 1 mg/ml
Molekulargewicht:: 100 kDa
Quelle:: Animal
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Biotium
Host:: Mouse
Reaktivitäten:: Human, Mouse
Buffer:: PBS, no BSA, no azide|PBS, no BSA, no sodium azide
Immunogen:: Recombinant fragment (around aa 327-427) of human MSH2 protein (exact sequence is proprietary)
Formulierung:: PBS, no BSA, no azide
Klon:: MSH2/2622
Synonyme:: COCA1;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh2 transcript;FCC1;hMSH2;HNPCC;HNPCC1;LCFS2;MMRCS2;mutS homolog 2, colon cancer, nonpolyposis type 1
Weitere Details:: Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Versandbedingungen:: Ambient