BNUM2483
Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)(CPTC-PRDX4-2), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM2483
- Zusätzliche Namen:
- Antioxidant enzyme AOE372; EC 1.11.1.15; Thioredoxin dependent peroxide reductase A0372; TRANK
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 27 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant full-length human PRDX4 protein
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- CPTC-PRDX4-2
- Uniprot:
- Q13162
- Synonyme:
- AI642933;antioxidant enzyme AOE372;AOE37-2;AOE372;AP;AP-4;bHLHc4;bHLHc41;D930048N17Rik;epididymis secretory sperm binding protein Li 97n;HEL-S-97n;peroxiredoxin IV;peroxiredoxin-4;PRX-4;prx-IV;Tcfa;Tcfap4;thioredoxin peroxidase (antioxidant enzyme);thioredoxin peroxidase AO372;thioredoxin-dependent peroxide reductase A0372;thioredoxin-dependent peroxiredoxin 4;transcription factor AP-4;transcription factor AP-4 (activating enhancer-binding protein 4)
- Weitere Details:
- The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient