BNUM2283
Calcineurin A / PPP3CA(BF1.1), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM2283
- Zusätzliche Namen:
- Calcineurin A; Calcineurin A alpha; PPP3CA; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CALN; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA alpha; CNA1; Protein phosphatase 3 catalytic subunit alpha isoform
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 62 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant full-length Calcineurin A protein
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- BF1.1
- Uniprot:
- Q08209
- Synonyme:
- ACCIID;calcineurin A alpha;Calmodulin-dependent calcineurin A subunit alpha isoform;CALN;CALNA;CALNA1;CAM-PRP catalytic subunit;CCN1;CNA1;DEE91;IECEE;IECEE1;PPP2B;protein phosphatase 3 catalytic subunit alpha isozyme;serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
- Weitere Details:
- This antibody recognizes the Calcineurin A alpha protein, encoded by the PPP3CA (Protein Phosphatase 3 Catalytic Subunit Alpha) gene. Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient