BNUM1850
PD-L2 / PDCD1LG2 / CD273(PDL2/1850), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM1850
- Zusätzliche Namen:
- B7 dendritic cell molecule; B7-DC; B7DC; Btdc; Butyrophilin B7DC; CD273; PD-L2; PDCD1L2; PDCD1LG2; PDL2; Programmed death ligand 2
- Anwendung:
- Flow Cytometry
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 31 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- PDL2/1850
- Synonyme:
- B7 dendritic cell molecule;B7-DC;B7DC;bA574F11.2;Btdc;butyrophilin B7-DC;CD273;PD-1-ligand 2;PD-L2;PDCD1 ligand 2;PDCD1L2;PDL2;programmed cell death 1 ligand 2;programmed death ligand 2
- Weitere Details:
- Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient