BNUM1821
Langerin / CD207 (Marker of Langerhans Cells)(LGRN/1821), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM1821
- Zusätzliche Namen:
- C-type lectin domain family 4 member K; CD207; CLEC4K; Langerhans cell specific c type lectin; Langerin
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 48 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant fragment (around aa74-213) of human Langerin protein (exact sequence is proprietary)
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- LGRN/1821
- Uniprot:
- Q9UJ71
- Synonyme:
- C-type lectin domain family 4 member K;C-type lectin domain family 4, member K;CD207 antigen, langerin;CD207 molecule, langerin;cell adhesion molecule 4;CLEC4K;IGSF4C;immunoglobulin superfamily member 4C;Langerhans cell specific c-type lectin;Langerin;Necl-4;NECL4;nectin-like 4;nectin-like protein 4;synCAM4;TSLC1-like 2;TSLC1-like protein 2;TSLL2
- Weitere Details:
- Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2 -dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient