BNUM1748
Ubiquitin (Autophagy Marker)(UBB/1748), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM1748
- Zusätzliche Namen:
- Epididymis secretory protein Li 50; Polyubiquitin B; RPS27A; UBA52; UBA80; UBB; UBC; UBCEP1; UBCEP2
- Anwendung:
- Flow Cytometry, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 9 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant fragment of human Ubiquitin protein (around aa 1-119) (exact sequence is proprietary)
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- UBB/1748
- Uniprot:
- P62979, P62987, P62988
- Synonyme:
- 40S ribosomal protein S27a;CEP52;CEP80;E3 ubiquitin-protein ligase MARCH3;E3 ubiquitin-protein ligase MARCHF3;epididymis luminal protein 112;epididymis secretory protein Li 50;HEL-S-50;HEL112;HMG20;HUBCEP52;L40;MARCH-III;MARCH3;membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase;membrane-associated RING finger protein 3;membrane-associated RING-CH protein III;polyubiquitin B;polyubiquitin-B;polyubiquitin-C;RING-type E3 ubiquitin transferase MARCH3;RING-type E3 ubiquitin transferase MARCHF3;RPL40;S27A;UBA80;UBC;UBCEP1;UBCEP80;Ubiquitin A-52 residue ribosomal protein fusion product 1;ubiquitin and ribosomal protein S27a;ubiquitin C;ubiquitin carboxyl extension protein 52;ubiquitin carboxyl extension protein 80;ubiquitin-40S ribosomal protein S27a;ubiquitin-52 amino acid fusion protein;ubiquitin-60S ribosomal protein L40;ubiquitin-CEP52;ubiquitin-CEP80
- Weitere Details:
- Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease etc.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient