BNUM1525
E-Cadherin / CD324 (Intercellular Junction Marker) (CDH1/1525), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM1525
- Zusätzliche Namen:
- Arc 1|cadherin 1 type 1 E-cadherin|Cadherin1|CAM 120/80|CD324|CDH1|CDHE|E-Cad/CTF3|E-cadherin|ECAD|Epithelial cadherin|epithelial calcium dependent adhesion protein|Liver cell adhesion molecule (LCAM)|Uvomorulin (UVO)
- Anwendung:
- WB, IHC-P, IF
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 120-80 kDa (Mature); 135 kDa (Precursor)
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant human full-length E-Cadherin protein
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- CDH1/1525
- Uniprot:
- P12830
- Synonyme:
- Arc-1;BCDS1;cadherin 1, E-cadherin (epithelial);cadherin 1, type 1, E-cadherin (epithelial);cadherin-1;calcium-dependent adhesion protein, epithelial;CAM 120/80;CD324;CDHE;cell-CAM 120/80;E-cadherin 1;ECAD;epididymis secretory sperm binding protein;epithelial cadherin;LCAM;UVO;uvomorulin
- Weitere Details:
- This antibody recognizes a protein of 120-80 kDa, identified as E-cadherin. Cadherins comprise a family of Ca2 -dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as B Beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin ) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient