BNUM1244
Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (P-GF.44C), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM1244
- Zusätzliche Namen:
- ECGF; ECGF1; Gliostatin; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; Tymp
- Anwendung:
- WB, IHC-P
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 55 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- P-GF.44C
- Uniprot:
- P19971
- Synonyme:
- CELE_T07H6.5;ECGF;ECGF1;gliostatin;hPD-ECGF;MEDPS1;MNGIE;MTDPS1;PDECGF;Platelet-derived endothelial cell growth factor;tdRPase;thymidine phosphorylase;TP
- Weitere Details:
- This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient