BNUM0726
DOG-1(DG1/447 + DOG1.1), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM0726
- Zusätzliche Namen:
- Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
- Anwendung:
- IHC-P
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- ~114 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- DOG-1|TMEM16A|TMEM16A
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- DG1/447 DOG1.1
- Uniprot:
- Q5XXA6
- Synonyme:
- anoctamin 1, calcium activated chloride channel;anoctamin-1;Ca2+-activated Cl- channel;calcium activated chloride channel;discovered on gastrointestinal stromal tumors protein 1;DOG1;oral cancer overexpressed 2;Oral cancer overexpressed protein 2;ORAOV2;TAOS2;TMEM16A;Transmembrane protein 16A;transmembrane protein 16A (eight membrane-spanning domains);tumor-amplified and overexpressed sequence 2
- Weitere Details:
- Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient