BNUM0479
CD32 (Fc Gamma RIIa)(FCGR2A/479), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM0479
- Zusätzliche Namen:
- CD32A; Fc fragment of IgG low affinity IIa receptor; Fc gamma RIIa; FCGR2A; FcgRII; IGFR2; IgG Fc receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-a; Ly-17; Ly-m20; LyM-1; Lymphocyte antigen 17
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 40 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Recombinant human FCGR2A protein
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- FCGR2A/479
- Uniprot:
- P12318
- Synonyme:
- CD32;CD32A;CDw32;Fc fragment of IgG, low affinity IIa, receptor (CD32);Fc gamma receptor RIIa3;Fc-gamma RII-a;fc-gamma-RIIa;FCG2;FcGR;FCGR2;FCGR2A1;fcRII-a;IGFR2;igG Fc receptor II-a;Immunoglobulin G Fc receptor II;low affinity immunoglobulin gamma Fc region receptor II-a
- Weitere Details:
- This MAb binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i. e. , IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient