BNUM0224
Major Vault Protein (MVP)(1014), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM0224
- Zusätzliche Namen:
- Lung resistance-related protein (LRP); Major Vault Protein; MVP; VAULT1
- Anwendung:
- WB, IF
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- 104-110 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- Proteins precipitated from human breast cancer MCF-7 cells
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- 1014
- Uniprot:
- Q14764
- Synonyme:
- LRP;lung resistance-related protein;major vault protein;testicular secretory protein Li 30;VAULT1
- Weitere Details:
- Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient