BNUM0139
ACTH (Adrenocorticotrophic Hormone)(57), 1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUM0139
- Zusätzliche Namen:
- Pro-opiomelanocortin (POMC); Adrenocorticotropin; Adrenocorticotropic hormone; Melanocyte Stimulating Hormone (MSH); Melanotropin; beta-Endorphin; Lipotropin; Met-Enkephalin; POC
- Anwendung:
- IHC-P
- Konzentration:
- 1 mg/ml
- Molekulargewicht:
- ACTH is ~5 kDa, and the POMC precursor is ~30 kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.
- Quelle:
- Animal
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, no BSA, no azide|PBS, no BSA, no sodium azide
- Immunogen:
- N-terminal fragment of human ACTH conjugated to KLH
- Formulierung:
- PBS, no BSA, no azide
- Klon:
- 57
- Uniprot:
- P01189
- Synonyme:
- ACTH;adrenocorticotropic hormone;adrenocorticotropin;alpha-melanocyte-stimulating hormone;alpha-MSH;beta-endorphin;beta-LPH;beta-melanocyte-stimulating hormone;beta-MSH;CLIP;corticotropin-like intermediary peptide;corticotropin-lipotropin;EDH;gamma-LPH;gamma-MSH;HED;lipotropin beta;lipotropin gamma;LPH;melanotropin alpha;melanotropin beta;melanotropin gamma;met-enkephalin;MSH;NPP;OBAIRH;opiomelanocortin prepropeptide;POC;pro-ACTH-endorphin;pro-opiomelanocortin;proopiomelanocortin preproprotein
- Weitere Details:
- ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient