NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)(NKX3.1/3348), 0.2mg/mL

Eine Lieferung in diese Region ist nicht möglich.

SKU:: BNUB3348
Zusätzliche Namen:: NK3 Transcription Factor Related; Locus 1; NK Homeobox (Drosophila); Family 3; A; NK3 Transcription Factor Homolog A; NK Homeobox; Family 3; A; Homeobox Protein Nkx-3.1; BAPX2; NKX3
Anwendung:: IHC-P
Konzentration:: 0.2 mg/ml
Molekulargewicht:: 35 kDa
Quelle:: Animal
Lagerbedingungen:: 2-8[o]C, RT
Hersteller:: Biotium
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS, 0.05% BSA, 0.05% azide|PBS, 0.05% BSA, 0.05% sodium azide
Immunogen:: Recombinantfragment(around aa 92-224) of humanNKX3.1 protein (exact sequence is proprietary)
Formulierung:: PBS, 0.05% BSA, 0.05% azide
Klon:: NKX3.1/3348
Uniprot:: Q99801
Synonyme:: BAPX2;homeobox protein NK-3 homolog A;homeobox protein Nkx-3.1;NK homeobox, family 3, A;NK3 transcription factor homolog A;NK3 transcription factor related, locus 1;NKX3;NKX3.1;NKX3A
Weitere Details:: NKX3. 1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21. 2, which frequently undergoes a loss of heterozygosity. NKX3. 1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3. 1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3. 1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Versandbedingungen:: Ambient