BNUB2864
VISTA / GI24 (Negative Regulator of Immune Response)(VISTA/2864), 0.2mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUB2864
- Zusätzliche Namen:
- B7H5; DD1alpha; GI24; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; Stress-induced secreted protein 1 (SISP1); V domain Ig suppressor of T cell activation; V Set Immuno-regulatory Receptor
- Konzentration:
- 0.2 mg/ml
- Molekulargewicht:
- 34 kda
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- PBS, 0.05% BSA, 0.05% azide|PBS, 0.05% BSA, 0.05% sodium azide
- Immunogen:
- Recombinant full-length human VISTA protein
- Formulierung:
- PBS, 0.05% BSA, 0.05% azide
- Klon:
- VISTA/2864
- Uniprot:
- Q9H7M9
- Synonyme:
- B7-H5;B7H5;C10orf54;DD1alpha;Death Domain1alpha;Dies1;GI24;PD-1H;PDCD1 homolog;platelet receptor GI24;PP2135;sisp-1;SISP1;stress-induced secreted protein-1;V-domain Ig suppressor of T cell activation;V-set domain-containing immunoregulatory receptor;V-set immunoregulatory receptor;V-type immunoglobulin domain-containing suppressor of T-cell activation;VISTA
- Weitere Details:
- VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment). It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient