BNUB2784
AKT1 (Prognostic Marker for Neuroendocrine Tumors)(AKT1/2784), 0.2mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUB2784
- Zusätzliche Namen:
- AKT1; PKB; Protein Kinase B Alpha; RAC-alpha serine/threonine-protein kinase
- Anwendung:
- WB, IHC-P
- Konzentration:
- 0.2 mg/ml
- Molekulargewicht:
- 62 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- PBS, 0.05% BSA, 0.05% azide|PBS, 0.05% BSA, 0.05% sodium azide
- Immunogen:
- Recombinant fragment of human AKT1 protein (around aa 85-189) (exact sequence is proprietary)
- Formulierung:
- PBS, 0.05% BSA, 0.05% azide
- Klon:
- AKT1/2784
- Uniprot:
- P31749
- Synonyme:
- AKT;AKT1m;PKB;PKB alpha;PKB-ALPHA;PRKBA;Protein kinase B;protein kinase B alpha;proto-oncogene c-Akt;RAC;rac protein kinase alpha;RAC-ALPHA;RAC-alpha serine/threonine-protein kinase;RAC-PK-alpha;serine-threonine protein kinase;v-akt murine thymoma viral oncogene homolog 1;v-akt murine thymoma viral oncogene-like protein 1
- Weitere Details:
- This antibody recognizes a protein of 62 kDa, which is identified as AKT1. The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBbeta or RacPK-beta) and Akt3 (also designated PKB-gamma or thymoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-beta tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s), and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient