BNUB2089
Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) (SOD1/2089), 0.2mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUB2089
- Zusätzliche Namen:
- Amyotrophic lateral sclerosis 1 (ALS1); Cu/Zn SOD; Cu/Zn Superoxide Dismutase; Epididymis Secretory Protein Li 44; Indophenoloxidase A (IPOA); Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1 (SOD1)
- Konzentration:
- 0.2 mg/ml
- Molekulargewicht:
- 23 kda
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- PBS, 0.05% BSA, 0.05% azide|PBS, 0.05% BSA, 0.05% sodium azide
- Immunogen:
- Recombinant full-length human SOD1 protein
- Formulierung:
- PBS, 0.05% BSA, 0.05% azide
- Klon:
- SOD1/2089
- Uniprot:
- P00441
- Synonyme:
- ALS;ALS1;Cu/Zn superoxide dismutase;epididymis secretory protein Li 44;HEL-S-44;homodimer;hSod1;indophenoloxidase A;IPOA;SOD;SOD, soluble;STAHP;superoxide dismutase [Cu-Zn];Superoxide dismutase 1;superoxide dismutase 1, soluble;superoxide dismutase, cystolic
- Weitere Details:
- Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient