BNUB1898
DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), 0.2mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUB1898
- Zusätzliche Namen:
- DNA methyltransferase 3 alpha; DNA methyltransferase HsaIIIA; DNAMTaseHsaIIIA; DNMT; DNMT3A2; M.HsaIIIA; MCMT; TBRS
- Anwendung:
- IHC-P
- Konzentration:
- 0.2 mg/ml
- Molekulargewicht:
- 102 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- PBS, 0.05% BSA, 0.05% azide|PBS, 0.05% BSA, 0.05% sodium azide
- Immunogen:
- Recombinant full-length human DNMT3A protein
- Formulierung:
- PBS, 0.05% BSA, 0.05% azide
- Klon:
- PCRP-DNMT3A-1E2
- Uniprot:
- Q16655
- Synonyme:
- antigen LB39-AA;antigen SK29-AA;cysteine methyltransferase DNMT3A;DNA (cytosine-5-)-methyltransferase 3 alpha;DNA (cytosine-5)-methyltransferase 3A;DNA cytosine methyltransferase 3A2;DNA MTase HsaIIIA;DNMT3A2;epididymis secretory sperm binding protein;HESJAS;M.HsaIIIA;MART-1;MART1;melanoma antigen recognized by T-cells 1;protein Melan-A;TBRS
- Weitere Details:
- The specificity of this monoclonal antibody to its intended target was validated by HuProt™Array, containing more than 19,000, full-length human proteins. DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient