MMP3 (Marker of Metastasis and Rheumatoid Arthritis)(1B4), 0.2mg/mL

Eine Lieferung in diese Region ist nicht möglich.

SKU:: BNUB1729
Zusätzliche Namen:: CHDS6; Matrix metalloproteinase 3; Matrix metalloproteinase-3; MMP3; Proteoglycanase; SL1; STMY1; STR1; Stromelysin-1; Transin 1
Anwendung:: WB, IHC-P
Konzentration:: 0.2 mg/ml
Molekulargewicht:: 57 kDa
Quelle:: Animal
Lagerbedingungen:: 2-8[o]C, RT
Hersteller:: Biotium
Host:: Mouse
Reaktivitäten:: Bovine, Human, Mouse
Buffer:: PBS, 0.05% BSA, 0.05% azide|PBS, 0.05% BSA, 0.05% sodium azide
Immunogen:: Recombinant fragment corresponding to amino acids 317-327 of human MMP3.
Formulierung:: PBS, 0.05% BSA, 0.05% azide
Klon:: 1B4
Uniprot:: P08254
Synonyme:: CHDS6;matrix metalloproteinase 3 (stromelysin 1, progelatinase);Matrix metalloproteinase-3;MMP-3;proteoglycanase;SL-1;STMY;STMY1;STR1;stromelysin-1;transin-1
Weitere Details:: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Versandbedingungen:: Ambient